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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TLK2 All Species: 28.18
Human Site: S44 Identified Species: 62
UniProt: Q86UE8 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q86UE8 NP_001106178.1 772 87661 S44 Q S L C S V G S L S D K E V E
Chimpanzee Pan troglodytes XP_523598 848 95816 S142 Q S L C S V G S L S D K E V E
Rhesus Macaque Macaca mulatta XP_001107302 907 100501 S182 Q S L C S V G S L S D K E V E
Dog Lupus familis XP_548038 918 102784 S212 Q S L C S V G S L S D K E V E
Cat Felis silvestris
Mouse Mus musculus O55047 718 82242 S44 Q S L C S V G S L S D K E V E
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515053 718 81881 S55 H S F G S L G S L S D K E S E
Chicken Gallus gallus XP_418070 750 85456 S44 Q S L C S V G S L S D K E L E
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q1ECX4 697 79286 G43 N Q S L C S V G S L S D K E L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_624065 793 90042 S59 S T V N S G Q S V H S Q D S N
Nematode Worm Caenorhab. elegans P34314 965 109255 A69 G T V S S T M A T G D T G R V
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q39238 688 78131 G34 K L E A R L T G K T P S S A K
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 88.3 82.3 81.2 N.A. 92.4 N.A. N.A. 68.6 94.1 N.A. 77.9 N.A. N.A. 47.9 36.5 N.A.
Protein Similarity: 100 88.3 83 81.3 N.A. 92.7 N.A. N.A. 77.7 95.8 N.A. 83.9 N.A. N.A. 63.4 50.1 N.A.
P-Site Identity: 100 100 100 100 N.A. 100 N.A. N.A. 66.6 93.3 N.A. 0 N.A. N.A. 13.3 13.3 N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 N.A. N.A. 73.3 100 N.A. 6.6 N.A. N.A. 46.6 33.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 35.3 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 50.2 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 0 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 10 0 0 0 10 0 0 0 0 0 10 0 % A
% Cys: 0 0 0 55 10 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 73 10 10 0 0 % D
% Glu: 0 0 10 0 0 0 0 0 0 0 0 0 64 10 64 % E
% Phe: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 10 0 0 10 0 10 64 19 0 10 0 0 10 0 0 % G
% His: 10 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 10 0 0 0 0 0 0 0 10 0 0 64 10 0 10 % K
% Leu: 0 10 55 10 0 19 0 0 64 10 0 0 0 10 10 % L
% Met: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % M
% Asn: 10 0 0 10 0 0 0 0 0 0 0 0 0 0 10 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % P
% Gln: 55 10 0 0 0 0 10 0 0 0 0 10 0 0 0 % Q
% Arg: 0 0 0 0 10 0 0 0 0 0 0 0 0 10 0 % R
% Ser: 10 64 10 10 82 10 0 73 10 64 19 10 10 19 0 % S
% Thr: 0 19 0 0 0 10 10 0 10 10 0 10 0 0 0 % T
% Val: 0 0 19 0 0 55 10 0 10 0 0 0 0 46 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _